Sequence Of Events for Vascular Cellular Repair and the Inflammation Response A break in the skin occurs Bacterial reproduction increases Macrophages engulf bacteria Macrophages secrete cytokines Activated mast cells secrete histamine Histamine and cytokines increase dilation of blood vessels White blood cells (WBCs) adhere to capillary lining (pavementing) WBCs migrate to injured site via endothelial cellular gaps via diapedis movement Monocytes turn into macrophages Macrophages and neutrophils engulf pathogens (phagocytosis) Red Blood Cells increase in concentration causing redness and head An increased amount of fluid migrates to the area causing swelling and pain. Tissue repair commences and systemic responses may be evident e.g. fever What is involved in the tissue repair response? Resolution – the toxin is neutralized, oedema decreases, capillary permeability decreases and vasoconstriction occurs Regeneration & replacement – proliferation...
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